Prediction of Physicochemical, Pharmacokinetic and Toxicological Parameters of Antimicrobials in Phase III Clinical Studies
In silico analysis importance was recognized. It provides a predictive evaluation of the molecular behavior, revealing physicochemical properties and pharmacokinetic and toxicological informations that determine how much promising is a molecule to advance to other pharmaceutical tests. Therefore, this work aimed to present the traditional antimicrobials in phase III clinical studies, attaching, through in silico analysis, their pharmacokinetics, adverse effects and toxicity to their molecular structure and physicochemical properties.