Therapeutic property of propolis extract in systemic infection induced in rats
Propolis is a natural product used to treat inflammation and microbial infections. This study was performed to evaluate the effects of standardized propolis extract in behavioral and cognitive changes resulting from systemic infection. These changes were evaluated in Wistar rats anesthetized before the surgical procedure of cecal ligation and puncture. They were administered with the antibiotics clindamicine (25 mg/kg) plus gentamicin (3 mg/kg) or propolis extract (100 mg/kg). The control animals received neither ligation nor perforation.