Effects of administration of unnatured collagen type II (UC-II) in knee osteoarthritis: a placebo-controlled, double-blind randomized clinical Trial
Purpose: Approximately 25% of people 55 and older have had knee pain, and about half of them have symptomatic knee osteoarthritis (OA). A new nutraceutical, undenatured collagen II (UC-II), has been studied in knee OA patients. The objective was to evaluate the effect of using undenatured type II collagen in subjects with knee OA. Methods: A double-blind, placebo-controlled, randomized controlled trial with 40 patients with grade I-III knee OA, randomized into collagen group (CG) and placebo collagen group (PCG).