Tricholeukemia and therapeutic perspectives in a refractory case
Tricholeukemia, also called hairy cell leukemia, is a chronic B-cell lymph proliferative neoplasm. It is a rare, more frequent disease in males. The clinical presentation is characterized by cytopenia, splenomegaly and non-specific symptoms such as asthenia and weight loss. The diagnosis is performed by immuno-phenotyping of bone marrow by flow cytometry, and the BRAFV600V mutation is present in most cases. Therapy is usually dramatic with purine analogues and other alternatives include newer drugs such as the BRAFV600E inhibitors.