Promethazine theoclate, a first-generation H1 receptor blocker, is commonly prescribed for motion sickness and postoperative nausea. Its oral bioavailability is only about 25%, mainly because of poor solubility in water, which delays the onset of action. To overcome this limitation, orally disintegrating tablets (ODTs) of promethazine theoclate were developed.
Liquisolid technology is an effective technique for enhancing the solubility and dissolution properties of poorly water-soluble drugs. Miconazole, a broad-spectrum antifungal agent, is classified as a BCS Class II drug due to its limited water solubility and high lipophilicity, resulting in low oral bioavailability (approximately 25-30%) and an elimination half-life of 24 hours. This study aimed to improve the solubility and dissolution rate of miconazole using liquisolid technology and develop a mucoadhesive tablet formulation for buccal administration.
Anatomical variations in the abdominal cavity are critical for surgical planning and ensuring safe, effective procedures. Variants of the superior mesenteric artery are not uncommon and provide important insights into clinical conditions. In the dissection of a male cadaver, approximately 60 years old, a common trunk was observed arising from the superior mesenteric artery, giving rise to the right colic and ileocolic arteries. The anterior and posterior cecal branches were also identified.
Objetivo: O objetivo foi desenvolver e validar tabela de classificação para o índice de condicionamento físico de idosos. Método: Foram analisados estatisticamente os resultados das avaliações de 133 idosas com idades entre 60 a 79 anos, avaliadas pelo protocolo (IFCI), composto por testes de força e resistência muscular, flexibilidade, composição corporal e resistência aeróbica. Adotou-se 5 critérios de classificação (muito baixo, baixo, regular, alto e muito alto) a partir da distribuição por centis.
A produção de morango na Bahia tem ganhado destaque, especialmente na Chapada Diamantina, com ênfase no município de Boninal-BA, onde agricultores familiares cultivam majoritariamente a variedade San Andreas. Pernambuco é o principal destino da produção. Após a detecção de resíduos de agrotóxicos, o Ministério Público Estadual (MPE) acionou a Agência de Defesa Agropecuária da Bahia (ADAB). Este estudo teve como objetivo mapear doenças da cultura e orientar produtores sobre o uso seguro de agrotóxicos e o descarte correto das embalagens vazias.
Diabetes mellitus is a complex and progressive metabolic disorder that continues to pose a significant global health challenge. Current therapeutic strategies, although effective, are often accompanied by side effects, reduced patient compliance, and economic burden, which has fueled the search for safer and more sustainable alternatives. Among various medicinal plants, Camellia sinensis (green tea) has received particular attention due to its rich content of bioactive catechins, especially epigallocatechin gallate (EGCG).
Clinical laboratories play a pivotal role in healthcare by serving as the foundation of accurate disease detection, diagnosis, monitoring, and prognosis. With advancements in technology, laboratories have become integral to ensuring precision medicine, enabling early detection of diseases, and guiding therapeutic decisions. Approximately 70% of clinical decisions are based on laboratory results, underlining their significance in patient care.
Feridas crônicas resultam de danos que interrompem a cicatrização, sendo as úlceras venosas uma das mais comuns, responsáveis por 70 a 90% das úlceras de membros inferiores. Embora a mortalidade seja baixa, elas causam significativa morbidade, desconforto e incapacidade, afetando a qualidade de vida dos pacientes. O impacto social e econômico é grande devido à natureza recorrente e ao longo tempo de cicatrização. As recidivas elevadas representam um desafio no tratamento.
Ventilator-associated pneumonia (VAP) is a significant hospital-acquired infection in patients requiring mechanical ventilation for more than 48 hours following endotracheal intubation. In critically ill individuals, VAP increases mortality risk, prolongs ventilator dependence, extends hospital stays, and raises healthcare costs. This prospective study was conducted on sixty mechanically ventilated patients admitted to the critical care units of IPGMER and SSKM Hospital, with VAP diagnosed using the modified Clinical Pulmonary Infection Score (CPIS > 6).
Este artículo reporta un estudio cualitativo con diseño narrativo que exploró las concepciones de docentes de la comuna de Ancud sobre el Aprendizaje Profundo/AP. Mediante el Método de Análisis Paradigmático aplicado a las narrativas de 36 docentes (N=36) durante el año escolar 2024, los resultados revelan la ausencia de consenso conceptual formal, siendo el AP interpretado primariamente como conocimiento tácito/experiencial.