Unicystic ameloblastoma is a benign epithelial odontogenic neoplasm that represents about 5 to 15% of all intraosseous ameloblastomas, its biological behavior is related to its histopathological subtypes, with the mural variant being the most aggressive. The objective of this systematic review was to evaluate in the scientific literature the effectiveness of the conservative and radical surgical approach in the treatment of unicysticameloblastomas. A systematic literature review was performed using the Science Direct, Embase, Cochrane Collaboration Library, and PubMed/MEDLINE databases.