Long-term effects of metoprolol and ivabradine in reperfused anterior myocardial infarction: met-iva study (clinical findings after 8 years of follow-up)
Background: Heart rate is a determinant of myocardial oxygen demand and in myocardial infarction it is related to mortality. Ivabradine is a pure cardiac agent that reduces speed and has no effect on blood pressure and contractility and can reverse left ventricular remodeling. B-blockers in ST-elevated myocardial infarction (STEMI) are indicated for patients without a contraindication, particularly in patients with high heart rate or blood pressure. Epidemiological studies have shown that the increase in CF represents a risk factor for cardiovascular morbidity.