LPS-challenged mice kidney and modulatory effect of Simvastatin
Background: Lipopolysaccharide (LPS) is recognized by the innate immune system. This study was designed to investigate the effects of simvastatin on LPS-induced renal oxidative and immunological changes of mice. Methods: Male Swiss mice were injected with LPS (1 mg/kg; i.p.) and the effects of pretreatment with simvastatin (10 mg/kg; i.p.) on LPS-induced renal failure and kidney pathology were examined 3 hours post LPS injection. Plasma concentrations of urea, creatinine and lactate dehydrogenase (LDH) activity as well as kidney contents of interleukin-1β (IL-1β) and IL-10 were assessed.