A glance to diabetic peripheral neuropathy
Neuropathic pain is defined as "pain initiated or caused by a primary lesion or dysfunction in the nervous system." Painful diabetic neuropathy (PDN) affects 16% of patients with diabetes, and it is frequently unreported (12.5%) and more frequently untreated (39%). Neuropathic pain is poorly managed by NSAIDs, and opioids have limited effectiveness because high doses are associated with adverse events. Treatments are needed for neuropathic pain that are effective but that cause a minimal risk of dependence or of other negative impacts on a patient's quality of life.