Health Sciences

Background: Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immune compromised individuals. Although, it was hypothesized that HCMV might be associated with colorectal cancer progression. However, the role of HCMV infection in colorectal cancer remains controversial.
Objectives: Detection of cytomegaloviral DNA in cells of colorectal cancer among Iraqi patients by polymerase chain reaction (PCR).

P-phenylenediamine (PPD) is a monocyclic arylamine frequently used as a component in permanent hair dyes, inks and certain tattoos. It has been reported that a number of hair dye constituents including monocyclic PPD have genotoxic properties in experimental systems. In this study, the molecular mechanism of PPD, a suspected carcinogen, induced cell death in murine myeloma cells P3X63Ag8.653 (P3) was investigated. Apoptosis was evaluated by DAPI staining and DNA gel electrophoresis. The activity of caspase-8, -3 and -9 was assessed by spectrophotometry using colorimetric tests.

Cadmium is a nonessential trace element with no biological function. It accumulates rapidly by most living organisms and exerts its toxicity at different molecular levels. The present study was undertaken to study the tissue accumulation of cadmium and changes in oxidative stress indices due to this ubiquitous environmental pollutant following experimental daily oral administration and to examine the ameliorative property of thiamine, methionine and garlic extract on cadmium-induced oxidative damage.

An experiment was conducted in the Department of Poultry Science, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University to evaluate the effect of various sanitizing agents on the microbial and duckling qualities of hatching eggs of Kuttand duck (Anas platyrhynchos domesticus) eggs. A total of 2400 hatching eggs over a period of six weeks was collected for the study. Each treatment consisted of 600 eggs with 100 eggs per replicate.

The pilot study was conducted on 10 adult albino rats of either sex 150-200gm each. Two equal groups of control and experimental was made. The control group received food and water ad libitum whereas experimental group received 30 ppm of NaF for 8 weeks. The macroscopic features like body weight, general activity was markedly reduced in experimental group pertaining to high fluoride levels in the brain. Light microscopy of cerebrum in experimental group revealed decreased density of neurons, high mitotic figures.

This study was conducted to evaluate the effects of oestrus synchronization protocol on oestrus response, pregnancy rate, progesterone (P4) and cortisol concentrations in Nelore cattle under two different types of handlings. In Experiment I (heavy handling), 27 cows were selected and subdivided into four groups, namely the Control, Groups 1, 2 and 3. The Control group was treated with only CIDR inserts for 15 days.

Pneumonia is the most common invasive pneumococcal disease; however, only a small portion of cases can be confirmed by conventional techniques. The present study aimed at comparing the molecular detection of Streptococcal pneumoniae by the standard blood culture in community-acquired pneumonia among Egyptian children. Standard blood culture of Streptococcal pneumoniae and sequence-specific PCR amplification of autolysin gene were performed. There was a statistically significant increase in PCR diagnosed cases than that diagnosed by blood culture with higher PCR sensitivity.

This review highlights the urgent need of natural medicine to counter the side effects and to reduce the death rates of cancer. The modern drugs fail to meet the expectations of the novel drug due the properties of the cancer cells. Moreover the present day treatments are patient specific rather than type of tumor stage specific, hence new diagnostic tools are needed towards the cancer diagnosis. Nowadays marine source are gaining more and more importance because of its potentiality. So search of marine drugs for new therapeutic uses is an efficient approach to drug discovery.   

A generic drug is a pharmaceutical product, usually intended to be interchangeable with an innovator product, that is manufactured without a license from the innovator company and marketed after the expiry date of the patent or other exclusive rights. One mechanism to reduce pharmaceutical spending is to increase utilization of generic medications in daily practice, but there are many ethical issues inherent in utilizing brand name versus generic medications.

Worldwide are held about 16,000 transplants of stem cells autologous and 29,000 allogeneic. In Brazil, the stem cell transplant autologous bone marrow transplantation increases about 1,000 per year. Cell therapy or transplantation of Hematopoietic Stem Cells (HSC) is a regenerative medicine that aims to restore and regenerate the functions of senescent cells or tissues with serious injuries. The CTH constitute from 0.05% to 0.1% of human bone marrow and circulating haematopoietic cells. The phenotype of hematopoietic stem cells include CD 34 antigen expression of the (+) and CD133 (+).